node.js apps that use the popular express framework can be hosted in IIS.
code
var express = require('express');
var app = express.createServer();
app.get('/node/express/myapp/foo', function (req, res) {
    res.send('Hello from foo! [express sample]');
});
app.get('/node/express/myapp/bar', function (req, res) {
    res.send('Hello from bar! [express sample]');
});
app.listen(process.env.PORT);
    web.config
<configuration>
  <system.webServer>
    <!-- indicates that the hello.js file is a node.js application 
    to be handled by the iisnode module -->
    <handlers>
      <add name="iisnode" path="hello.js" verb="*" modules="iisnode" />
    </handlers>
    <!-- use URL rewriting to redirect the entire branch of the URL namespace
    to hello.js node.js application; for example, the following URLs will 
    all be handled by hello.js:
    
        http://localhost/node/express/myapp/foo
        http://localhost/node/express/myapp/bar
        
    -->
    <rewrite>
      <rules>
        <rule name="myapp">
          <match url="myapp/*" />
          <action type="Rewrite" url="hello.js" />
        </rule>
      </rules>
    </rewrite> 
    
  </system.webServer>
</configuration>